Anticholinergic‐induced chorea in the treatment of focal dystonia
Identifieur interne : 006632 ( Main/Exploration ); précédent : 006631; suivant : 006633Anticholinergic‐induced chorea in the treatment of focal dystonia
Auteurs : M. Nomoto [Royaume-Uni] ; P. D. Thompson [Royaume-Uni] ; M. P. Sheehy [Royaume-Uni] ; N. P. Quinn [Royaume-Uni] ; C. D. Marsden [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1987.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Aged, Chemotherapy, Chorea, Chorea (chemically induced), Drug Administration Schedule, Dystonia, Dystonia (drug therapy), Female, Focal dystonia, Human, Humans, Male, Middle Aged, Nervous system diseases, Parasympatholytic, Toxicity, Trihexyphenidyl, Trihexyphenidyl (administration & dosage), Trihexyphenidyl (adverse effects).
- MESH :
- chemical , administration & dosage : Trihexyphenidyl.
- chemical , adverse effects : Trihexyphenidyl.
- chemically induced : Chorea.
- drug therapy : Dystonia.
- Adult, Aged, Drug Administration Schedule, Female, Humans, Male, Middle Aged.
Abstract
The occurrence of chorea, induced by trihexyphenidyl (benzhexol hydrochloride) during the treatment of five adult patients who had focal or segmental dystonia, is described. The dose at which chorea appeared ranged from 15 to 60 mg/day (mean 31.7 mg/day). All but one patient had developed common adverse effects of this drug (dry mouth, blurred vision, and confusion) at lower doses (mean 21.8 mg per day). There was an inverse relationship between the age of the patient and the dose of trihexyphenidyl at which chorea developed.
Url:
DOI: 10.1002/mds.870020107
Affiliations:
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Le document en format XML
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Marsden</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>University Department of Neurology and Parkinson's Disease Society Research Centre, Institute of Psychiatry and King's College Hospital Medical School, Denmark Hill, London</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1987">1987</date><biblScope unit="vol">2</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="53">53</biblScope><biblScope unit="page" to="56">56</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1E69C27CD7DBA0B1C1F446A4FC4B4CCA961487E4</idno><idno type="DOI">10.1002/mds.870020107</idno><idno type="ArticleID">MDS870020107</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Chemotherapy</term><term>Chorea</term><term>Chorea (chemically induced)</term><term>Drug Administration Schedule</term><term>Dystonia</term><term>Dystonia (drug therapy)</term><term>Female</term><term>Focal dystonia</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parasympatholytic</term><term>Toxicity</term><term>Trihexyphenidyl</term><term>Trihexyphenidyl (administration & dosage)</term><term>Trihexyphenidyl (adverse effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Trihexyphenidyl</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Trihexyphenidyl</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Chorea</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Drug Administration Schedule</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chimiothérapie</term><term>Chorée syndrome</term><term>Dystonie</term><term>Homme</term><term>Parasympatholytique</term><term>Système nerveux pathologie</term><term>Toxicité</term><term>Trihexyphénidyle</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The occurrence of chorea, induced by trihexyphenidyl (benzhexol hydrochloride) during the treatment of five adult patients who had focal or segmental dystonia, is described. The dose at which chorea appeared ranged from 15 to 60 mg/day (mean 31.7 mg/day). All but one patient had developed common adverse effects of this drug (dry mouth, blurred vision, and confusion) at lower doses (mean 21.8 mg per day). There was an inverse relationship between the age of the patient and the dose of trihexyphenidyl at which chorea developed.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Nomoto, M" sort="Nomoto, M" uniqKey="Nomoto M" first="M." last="Nomoto">M. Nomoto</name></region><name sortKey="Marsden, C D" sort="Marsden, C D" uniqKey="Marsden C" first="C. D." last="Marsden">C. D. Marsden</name><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N. P." last="Quinn">N. P. Quinn</name><name sortKey="Sheehy, M P" sort="Sheehy, M P" uniqKey="Sheehy M" first="M. P." last="Sheehy">M. P. Sheehy</name><name sortKey="Thompson, P D" sort="Thompson, P D" uniqKey="Thompson P" first="P. D." last="Thompson">P. D. Thompson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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